In a personal, nontechnical, and informal style, eminent researcher Ira L. Reiss discusses the many situations he has encountered during the past fifty years while researching sexuality and developing useful and innovative explanations of its different aspects. Most of the problems that were present during those years are still confronting those who work on human sexuality. Reiss discusses his experiences in sexual science in areas such as premarital sex, the sexual revolution, Masters and Johnson's therapy, feminism and sexuality, crises in sexual organizations, responses to HIV/AIDS, child and adolescent sexuality, radical social constructionism, biology versus sexual science, international trends, and the movement toward a Ph.D. in sexual science. The insights and solutions Reiss proposes are of great importance to all those who are interested in the sexual issues that affect people today.